Association between serum total cholesterol and HIV infection in a high-risk cohort of young men
Association between serum total cholesterol and HIV infection in a high-risk cohort of young men
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DOI：
10.1097/00042560-199801010-00008
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发表时间：
1998-01-01
期刊：
影响因子：
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通讯作者：
Feingold, KR
中科院分区：
文献类型：
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作者：
Claxton, AJ;Jacobs, DR;Feingold, KR
低血清总胆固醇与多种非动脉粥样硬化性疾病有关，但TC与感染性疾病的关系研究很少。在这项研究中，我们研究了北方加州的一个大型健康维护组织的成员血清TC和HIV感染之间的关系。该队列由2446名年龄在15至49岁之间的未婚青年男性组成，他们具有HIV感染的高风险，定义为自我报告的性传播疾病或肝病史。基线测量是在1979年至1985年之间进行的，受试者被动地随访HIV感染，直到1993年底（平均随访时间为7.7年）。多变量校正后的考克斯回归分析显示，血清TC水平升高的男性HIV感染率比（RR）为1.66（95%CI = 1.07，2.56
Low serum total cholesterol CTC) is associated with a variety of nonatherosclerotic diseases, but the association of TC with infectious disease has been little studied. In this study, we examined the relationship between serum TC and HIV infection in members of a large health maintenance organization in Northern California. The cohort consisted of 2446 unmarried young men 15 to 49 years of age at high risk of HIV infection, defined as self-reported history of sexually transmitted disease or liver disease. Baseline measurements were taken between 1979 and 1985, and subjects were passively followed for HIV infection until the end of 1993 (average length of follow-up, 7.7 years). From a multivariate-adjusted Cox regression, the rate ratio (RR) of HIV infection was 1.66 (95% CI = 1.07, 2.56) for men with serum TC levels