Aging effects on osteon remodeling
Aging effects on osteon remodeling
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衰老对骨重塑的影响
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
D. Ortner
中科院分区：
文献类型：
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作者：
D. Ortner
对101例人胫骨部分横截面的分析表明，外皮层骨重塑受年龄的影响。吸收空间的频率在整个生命中保持不变，这表明破骨细胞的功能不会随着年龄的增长而丧失。然而，随着年龄的增长，形成骨和结构完整但未完全矿化的骨的频率都增加了。这表明成骨细胞的蛋白质基质合成随着年龄的增长而减慢，初始矿化（可能由成骨细胞介导）和最终矿化（可能由骨细胞介导）随着年龄的增长而日益缺乏。骨内片致密（硬化）的频率随着年龄的增长而减少。这支持了一种假设，即这种骨片是功能性的，可能代表了一种特殊的、不稳定的矿物阶段，并且具有这种特征的骨在与衰老相关的一般退行性变化中变得不那么频繁。
Analysis of partial cross sections of 101 human tibiae indicated that osteon remodeling in the outer cortex is affected by age. The frequency of resorption spaces remained constant throughout life suggesting no loss of osteoclast function with age. However, the frequency of both forming osteons and osteons which were structurally complete but not completely mineralized increased with age. This suggests that protein matrix synthesis by osteoblasts slows with age and that initial mineralization, possibly mediated by osteoblasts, and final mineralization, possibly mediated by osteocytes, becomes increasingly deficient with increasing age. The frequency of osteons which have dense (sclerotic) inner lamellae decreases with age. This supports a hypothesis that such lamellae are functional, perhaps representing a specialized, labile, mineral phase and that osteons having this feature become less frequent as part of the general degenerative changes associated with aging.