Prediction of gene function in methylthioadenosine recycling from regulatory signals
Prediction of gene function in methylthioadenosine recycling from regulatory signals
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DOI：
10.1128/jb.184.8.2314-2318.2002
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发表时间：
2002-04-01
影响因子：
3.2
通讯作者：
Henkin, TM
中科院分区：
文献类型：
--
作者：
Murphy, BA;Grundy, FJ;Henkin, TM
S盒转录终止控制系统首先在枯草芽孢杆菌中被发现，用于调节基因表达以响应蛋氨酸的可获得性。S框基序的存在首次表明YKRTS和YKRW=基因可能在5‘-甲硫腺苷的循环中发挥作用，5’-甲硫腺苷是多胺生物合成的副产物，可以转化为蛋氨酸。在这项研究中，我们展示了ykrTS和ykrWXYZ基因产物在这一途径中的作用。
The S-box transcription termination control system, first identified in Bacillus subtilis, is used for regulation of gene expression in response to methionine availability. The presence of the S-box motif provided the first indication that the ykrTS and ykrW= genes could play a role in recycling of 5'-methylthioadenosine, a by-product of polyamine biosynthesis that can be converted to methionine. In this study we demonstrate a role for the ykrTS and ykrWXYZ gene products in this pathway.