Fyn in Neurodevelopment and Ischemic Brain Injury.
Fyn in Neurodevelopment and Ischemic Brain Injury.
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DOI：
10.1159/000369995
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发表时间：
2015
影响因子：
2.9
通讯作者：
Jiang X
中科院分区：
文献类型：
--
作者：
Knox R;Jiang X
Src家族激酶（SFKs）是一种非受体蛋白酪氨酸激酶，参与神经系统的许多正常和病理过程。SFKs Fyn, Src, Yes， Lyn和Lck在大脑中表达。本综述将重点关注Fyn，因为Fyn突变小鼠在大脑中具有惊人的表型，并且Fyn已被证明参与成年啮齿动物的缺血性脑损伤，以及我们在新生动物中的工作。了解Fyn在神经发育和疾病中的作用将使研究人员能够在保留保护性途径的同时瞄准病理途径。
The Src Family kinases (SFKs) are nonreceptor protein tyrosine kinases that are implicated in many normal and pathological processes in the nervous system. The SFKs Fyn, Src, Yes, Lyn and Lck are expressed in the brain. This review will focus on Fyn, as Fyn mutant mice have striking phenotypes in the brain and Fyn has been shown to be involved in ischemic brain injury in adult rodents, and with our work, in neonatal animals. An understanding of Fyn’s role in neurodevelopment and disease will allow researchers to target pathological pathways while preserving protective ones.