Thymic epithelium in AIDS. An immunohistologic study.
Thymic epithelium in AIDS. An immunohistologic study.
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艾滋病中的胸腺上皮。
DOI：
10.4049/jimmunol.142.9.2988
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
J. Bach
中科院分区：
文献类型：
--
作者：
W. Savino;M. Dardenne;C. Marche;D. Trophilme;J. Dupuy;D. Pekovic;N. Lapointe;J. Bach
作者利用免疫荧光技术研究了艾滋病患者胸腺上皮组织的结构和功能标记。艾滋病胸腺上皮网状结构消失；相反，发现了圆形或纺锤形细胞簇（根据它们的角蛋白含量来评估）。此外，经常观察到上皮坏死区域，细胞界限丧失。胸腺素含量降低，胸腺上皮分化抗原部分缺失。作者发现免疫球蛋白和补体系统元素直接与艾滋病胸腺上皮结合，但在任何对照研究中都没有，包括长期痛苦死亡的患者的胸腺。这些数据表明胸腺上皮可能是艾滋病的靶组织之一，可能是通过自身免疫破坏的间接机制。
The authors investigated by immunofluorescence the thymic epithelium from AIDS patients, using several structural and functional markers of this tissue. In AIDS thymus, the epithelial reticular pattern was lost; and instead, clusters of round or spindle-shaped cells (assessed by their keratin content) were found. In addition, regions of epithelial necrosis, with loss of cell limits, were frequently observed. Thymulin content was decreased, and a partial loss of differentiation antigens of the thymic epithelium was also detected. The authors showed the presence of immunoglobulins and elements of the complement system directly bound to AIDS thymic epithelium, but not in any of the controls studied, including thymuses from patients who died after a long period of agony. These data suggest that the thymic epithelium can be included among the target tissues in AIDS, possibly by an indirect mechanism of autoimmune destruction.
人类胸腺微环境：皮质胸腺上皮是胸腺微环境的抗原独特区域。
DOI：
--
发表时间：
1984
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
McFarland,EJ;Scearce,RM;Haynes,BF
通讯作者：
Haynes,BF