Folding of peptide models of collagen and misfolding in disease
Folding of peptide models of collagen and misfolding in disease
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DOI：
10.1016/s0959-440x(99)80016-5
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发表时间：
1999-02-01
影响因子：
6.8
通讯作者：
Brodsky, Barbara
中科院分区：
文献类型：
--
作者：
Baum, Jean;Brodsky, Barbara
三螺旋的错误折叠已被证明在胶原蛋白疾病中起关键作用。正常和突变的胶原蛋白三螺旋可以通过不同设计的短的合成肽来建模。NMR光谱和圆二色性的研究，这些肽模型的组装最近已被用来隔离折叠途径中的特定步骤，并提供了信息的变化所造成的突变。
The misfolding of the triple helix has been shown to play a critical role in collagen diseases. Normal and mutated collagen triple helices can be modeled by short, synthetic peptides of varying design. NMR spectroscopy and circular dichroism studies on the assembly of these peptide models have recently been used to isolate specific steps in the folding pathway and have provided information on the alterations resulting from mutations.