Memory performance in older trauma survivors - Implications for the longitudinal course of PTSD
Memory performance in older trauma survivors - Implications for the longitudinal course of PTSD
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DOI：
10.1196/annals.1364.006
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Yehuda, Rachel
中科院分区：
文献类型：
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作者：
Golier, Julia A.;Harvey, Philip D.;Yehuda, Rachel
在患有慢性创伤后应激障碍（PTSD）的青壮年中观察到陈述性记忆表现受损和海马体积变小。这些改变可能会使患有创伤后应激障碍（PTSD）的创伤幸存者在以后的生活中面临更大的认知能力下降的风险。本文重点关注有关老年创伤幸存者神经心理损伤的新兴文献，特别是老年退伍军人和大屠杀幸存者。在退伍军人和大屠杀幸存者中，与未暴露的受试者相比，创伤后应激障碍与学习、自由和暗示回忆以及识别记忆的严重损害有关；然而，两组中的创伤后应激障碍（PTSD）均不与记忆力受损或“快速遗忘”相关。此外，在这两个队列中，创伤后应激障碍与左右海马体积较小无关。随着年龄的增长，创伤后应激障碍与相当大的认知负担有关。有必要对老年受试者进行纵向研究，以检验 PTSD 是否与加速衰老或进行性记忆丧失有关。
Impaired declarative memory performance and smaller hippocampal volume have been observed in young and middle-aged adults with chronic posttraumatic stress disorder (PTSD). These alterations may put trauma survivors with PTSD at greater risk for cognitive decline in later life. This article focuses on the emerging literature on neuropsychological impairment in aging trauma survivors, in particular, elderly combat veterans and survivors of the Holocaust. In veterans and in Holocaust survivors, PTSD was associated with substantial impairments in learning, free and cued recall, and recognition memory compared to the respective nonexposed subjects; however, in neither group was PTSD associated with impaired retention or "rapid forgetting." Additionally, PTSD was not associated with smaller right or left hippocampal volume in either cohort. PTSD is associated with considerable cognitive burden with age. Longitudinal studies of older subjects are warranted to examine whether PTSD is associated with accelerated aging or progressive memory loss.