Copper‐Catalyzed Addition of Diboron Species
Copper‐Catalyzed Addition of Diboron Species
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DOI：
10.1002/9780470682531.pat0976
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发表时间：
2020-01
期刊：
影响因子：
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通讯作者：
A. Parra;Laura Trulli;M. Tortosa
中科院分区：
文献类型：
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作者：
A. Parra;Laura Trulli;M. Tortosa
硼酸及其衍生物是合成化学中用途广泛的中间体。现代硼化反应的发展促进了硼酸衍生物作为一类流行试剂的出现。近年来，催化硼化反应由于其效率、选择性和官能团兼容性而受到广泛关注。在这种背景下，铜催化的硼化反应已成为将硼酸酯引入有机分子的强大新工具。与其他过渡金属相比，铜的价格较低，毒性较小，而且硼基铜中间体独特的反应活性使这些工艺特别有吸引力。在本章中，我们将概述最重要的铜催化硼基化反应，这些反应涉及将铜（I）-硼基配合物加成到π键上。
Boronic acids and derivatives are highly versatile intermediates in synthetic chemistry. The development of modern borylation reactions has contributed to the emergence of boronic acid derivatives as a popular class of reagents. In recent years, catalytic borylation reactions have gained significant attention due to their efficiency, selectivity, and functional group compatibility. In this context, copper‐catalyzed borylations have become a powerful new tool for introducing boronic esters into organic molecules. The lower price and toxicity of copper versus other transition metals and the unique reactivity of the copper‐boryl intermediates make these processes particularly attractive. In this chapter, we will offer an overview of the most important copper‐catalyzed borylation reactions that involve addition of a copper(I)‐boryl complex to a π‐bond.