Rh phenotype, allele and haplotype frequencies among 51,857 blood donors in North India
Rh phenotype, allele and haplotype frequencies among 51,857 blood donors in North India
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DOI：
10.2450/2013.0300-12
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发表时间：
2014-01-01
影响因子：
3.7
通讯作者：
Rosamma, Nakamatathil L.
中科院分区：
文献类型：
--
作者：
Makroo, Raj;Gupta, Richa;Rosamma, Nakamatathil L.
背景本研究的目的是提供信息的Rh抗原，等位基因，表型和单倍型从我们的地区在印度的频率，并将它们与其他races.Materials和方法。这项观察性研究是在2009年3月至2011年8月期间使用全自动Rh血细胞分型系统对献血者进行的。收集数据并进行计算以确定抗原、表型、等位基因和单倍型频率。采用卡方检验比较本研究与其他研究的结果。本研究共纳入51，857名供体。最常见的Rh抗原是“e”。DCCee是我们研究中最常见的表型，我们的研究与世界不同地区的其他研究之间的表型分布存在显着差异。我们已经确定了北印度献血人群中Rh抗原和Rh表型的患病率，并推导出同一人群中的等位基因和单倍型频率。该人群Rh血型分布与其他人群不同。
Background. This study was performed to provide information on the frequencies of Rh antigens, alleles, phenotypes, and haplotypes from our region in India and to compare them with those from other races.Materials and methods. This observational study was conducted on blood donors from March 2009 to August 2011 using a fully automated system for Rh typing of blood cells. The data were collected and calculations done to determine the antigen, phenotypes, allele and haplotype frequencies. The chi square test was used for comparisons between the results of our study and those of other studies.Results. A total of 51,857 donors were included in this study. The most common Rh antigen found was "e". DCCee was the most prevalent phenotype in our study with the phenotype distribution being significantly different between our study and other studies from different regions of the world.Discussion. We have determined the prevalence of Rh antigens and Rh phenotypes in the North Indian blood donor population and derived the allele and haplotype frequencies in the same population. The Rh blood group distribution in this population was different from that in other populations.