CDK4: a master regulator of the cell cycle and its role in cancer.
CDK4: a master regulator of the cell cycle and its role in cancer.
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DOI：
10.18632/genesandcancer.221
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Reddy, E Premkumar
中科院分区：
文献类型：
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作者：
Baker, Stacey J;Poulikakos, Poulikos I;Irie, Hanna Y;Parekh, Samir;Reddy, E Premkumar
细胞周期部分由细胞周期蛋白及其相关的丝氨酸/苏氨酸细胞周期蛋白依赖性激酶或CDK调节。当细胞准备启动DNA合成时，CDK 4与D型细胞周期蛋白一起介导通过G1期的进展。虽然Cdk 4-null突变小鼠是可行的，并且由于其他CDK发挥的补偿作用，细胞增殖在体外没有受到显著影响，但该基因在哺乳动物发育和癌症中起着关键作用。本文综述了CDK 4在细胞周期控制、正常发育和肿瘤发生中的作用，以及目前被批准用作癌症治疗剂的小分子CDK 4/6抑制剂的现状和效用。
The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates progression through the G1 phase when the cell prepares to initiate DNA synthesis. Although Cdk4-null mutant mice are viable and cell proliferation is not significantly affected in vitro due to compensatory roles played by other CDKs, this gene plays a key role in mammalian development and cancer. This review discusses the role that CDK4 plays in cell cycle control, normal development and tumorigenesis as well as the current status and utility of approved small molecule CDK4/6 inhibitors that are currently being used as cancer therapeutics.