ALPHA-2-ADRENOCEPTOR-MEDIATED HYPERPOLARIZATION OF LOCUS COERULEUS NEURONS - INTRACELLULAR STUDIES INVIVO
ALPHA-2-ADRENOCEPTOR-MEDIATED HYPERPOLARIZATION OF LOCUS COERULEUS NEURONS - INTRACELLULAR STUDIES INVIVO
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DOI：
10.1126/science.6278591
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
VANDERMAELEN, CP
中科院分区：
文献类型：
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作者：
AGHAJANIAN, GK;VANDERMAELEN, CP
大鼠蓝斑去甲肾上腺素能神经元的体内细胞内记录显示，通过施用可乐定（一种α2-肾上腺素受体激动剂）或在细胞内脉冲诱发的尖峰爆发后，膜电位超极化；两种类型的超极化都与膜输入阻力的降低相关，并且两者都可以被α2-肾上腺素受体拮抗剂哌嗪阻断。由α2-肾上腺素受体介导的膜电位超极化显然是可乐定和激活诱导的蓝斑细胞放电抑制的基础。
Intracellular recordings in vivo from noradrenergic neurons of the rat locus coeruleus showed that membrane potential was hyperpolarized by the administration of clonidine (an .alpha.2-adrenoceptor agonist) or after a burst of spikes evoked by intracellular pulses; both types of hyperpolarization were associated with a decrease in membrane input resistance, and both could be blocked by the .alpha.2-adrenoceptor antagonist piperoxane. A hyperpolarization of membrane potential mediated by an .alpha.2-adrenoceptor apparently underlies both clonidine- and activation-induced inhibition of locus coeruleus cell firing.