Demonstration of MHC class II-restricted cytotoxic T lymphocytes in mice against herpes simplex virus.
Demonstration of MHC class II-restricted cytotoxic T lymphocytes in mice against herpes simplex virus.
复制标题
DOI：
--
复制
发表时间：
1990-09
期刊：
影响因子：
6.4
通讯作者：
G. Kolaitis;M. Doymaz;B. Rouse
中科院分区：
文献类型：
--
作者：
G. Kolaitis;M. Doymaz;B. Rouse
在人类中，CD4+主要组织相容性复合体（MHC）II类限制性T细胞主导细胞毒性T淋巴细胞（CTL）对单纯疱疹病毒（HSV）的反应，而在小鼠中，只有CD8+ MHC I类限制性CTL已被报道。在这项研究中，我们证明了一小部分（约30%）的反应，在引流淋巴结的急性局部HSV感染是由于CD4+ CTL小鼠。基于抗血清抑制研究、阴性耗竭方法以及它们对CD8+ MHC I类限制性CTL的不同抗原加工要求来鉴定此类CTL。本文还简要讨论了CD4+ CTL在局部感染中作为免疫调节剂的可能作用。
In humans CD4+ major histocompatibility complex (MHC) class II-restricted T cells dominate cytotoxic T-lymphocyte (CTL) responses to herpes simplex virus (HSV), whereas in the mouse only CD8+ MHC class I-restricted CTL have been reported. In this study, we demonstrate that a minor fraction (around 30%) of the response in draining lymph nodes of acute local HSV infections is attributable to CD4+ CTL mice. Such CTL were identified on the basis of antiserum inhibition studies, negative depletion approaches, as well as their differing antigen processing requirements to CD8+ MHC class I-restricted CTL. A possible role for CD4+ CTL as immunoregulators in local infections is discussed briefly.