CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach
CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach
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DOI：
10.1002/path.1741
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发表时间：
2005-04-01
影响因子：
7.3
通讯作者：
Wong, J
中科院分区：
文献类型：
--
作者：
Ko, S;Chu, KM;Wong, J
CDX2 和肝肠 (LI)-钙粘蛋白是肠道特异性标记物，两者在小肠和结肠中生理表达。最近的研究表明，CDX2 调节结直肠癌中 LI-钙粘蛋白基因 (CDH17) 的表达。本研究探讨了胃癌中 CDX2 和 LI-cadherin 表达的关系。从胃切除标本中收集了一百零九对肿瘤和非癌性胃粘膜。通过免疫组织化学染色测定 CDX2 和 LI-钙粘蛋白的蛋白表达水平。半定量RT-PCR显示，与非癌粘膜相比，CDX2和CDH17的mRNA在肿瘤中高表达。 CDX2 的过表达与胃腺癌中的 CDH17 显着相关。此外，CDX2 和 LI-钙粘蛋白的表达在肠化生中强烈耦合。总之，CDH17 的过度表达与 CDX2 显着相关。版权所有 (c) 2005 大不列颠及爱尔兰病理学会。由约翰·威利父子有限公司出版
CDX2 and liver-intestine (LI)-cadherin are intestine-specific markers and both are physiologically expressed in the small intestine and colon. Recent studies have demonstrated that CDX2 regulates LI-cadherin gene (CDH17) expression in colorectal cancer. The present study investigated the relationship of CDX2 and LI-cadherin expression in gastric cancer. One hundred and nine pairs of tumour and non-cancerous gastric mucosa were collected from gastrectomy specimens. Protein expression levels of CDX2 and LI-cadherin were determined by immunohistochemical staining. Semi-quantitative RT-PCR showed that the mRNAs of both CDX2 and CDH17 were highly expressed in tumour compared with noncancerous mucosa. Overexpression of CDX2 was significantly associated with CDH17 in gastric adenocarcinoma. Furthermore, the expression of CDX2 and LI-cadherin proteins was strongly coupled in intestinal metaplasia. In conclusion, overexpression of CDH17 is significantly associated with CDX2. Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.