Increased diurnal plasma concentrations of dehydroepiandrosterone in depressed patients
Increased diurnal plasma concentrations of dehydroepiandrosterone in depressed patients
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DOI：
10.1210/jc.83.9.3130
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发表时间：
1998-09-01
影响因子：
5.8
通讯作者：
Weber, B
中科院分区：
文献类型：
--
作者：
Heuser, I;Deuschle, M;Weber, B
下丘脑-垂体-肾上腺皮质系统的激活是抑郁症的生物核心症状。虽然在这种情况下皮质醇分泌的调节被很好地研究，但关于脱氢表雄酮(DHEA)分泌的昼夜活动的信息还没有。因此，我们研究了重度抑郁症患者(n=26)和健康对照组(n=33)的24小时DHEA血药浓度，发现抑郁症使DHEA的日最低血药浓度和日均血药浓度显著升高，而对DHEA的日最大血药浓度和日波幅无明显影响。特别是，我们发现平均脱氢表雄酮(5.8+/-3.6vs.3.4+/-1.9nmol/L；P<；0.003)、皮质醇(286+/-65vs.184+/-29nmol/L；P<；0.0001)和ACTH(7.14+/-2.06vs.5.72+/-1.36pmol/L；P<；0.002)血浆浓度：抑郁症患者白天脱氢表雄酮和皮质醇血浆浓度平行升高的新发现，对于调节慢性应激条件下的下丘脑-垂体-肾上腺皮质系统和抑郁症患者脱氢表雄酮治疗的理论基础具有重要意义。
Activation of the hypothalamus-pituitary-adrenocortical system is a biological core symptom of depression. Although the regulation of cortisol secretion is well studied in this condition, there is no information about the diurnal activity of dehydroepiandrosterone (DHEA) secretion. Therefore, we studied 24-h DHEA plasma concentrations (every 30 min) in severely depressed patients (n = 26) and healthy controls (n = 33).We found depression to significantly increase diurnal minimal and mean DHEA plasma concentrations, whereas there was no effect on the diurnal maximal plasma concentration and the diurnal amplitude of DHEA. In particular, we found a parallel increase in mean DHEA (5.8 +/- 3.6 vs. 3.4 +/- 1.9 nmol/L; P < 0.003), cortisol (286 +/- 65 vs. 184 +/- 29 nmol/L; P < 0.0001) and ACTH (7.14 +/- 2.06 vs. 5.72 +/- 1.36 pmol/L; P < 0.002) plasma concentrations.The novel finding of parallel increases in diurnal DHEA and cortisol plasma concentrations in depressed patients has important implications for the regulation of the hypothalamus-pituitary-adrenocortical system in conditions of chronic stress and for the rationale of DHEA treatment in depressed patients.