Peripheral to central: Organ interactions in stroke pathophysiology
Peripheral to central: Organ interactions in stroke pathophysiology
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周围到中枢：中风病理生理学中的器官相互作用
DOI：
10.1016/j.expneurol.2015.05.014
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发表时间：
2015-10-01
影响因子：
5.3
通讯作者：
Luo, Yumin
中科院分区：
文献类型：
--
作者：
Ma, Shubei;Zhao, Haiping;Luo, Yumin
中风与残疾和死亡的高风险相关，除了重组组织型纤溶酶原激活剂治疗急性中风外，大多数治疗方法已被证明无效。有希望的实验性治疗方法的临床翻译受到中风模型不足和对急性中风的发病机制及其如何影响预后的缺乏了解的限制。缺血脑和外周免疫系统之间的双向交流调节中风的进展和组织修复，而流行病学研究已经提供了器官功能障碍和中风风险之间存在关联的证据。这种串扰可以决定中风患者的命运，在研究中风的病理生理机制和治疗方案时必须考虑到这一点。本文综述了在基础和临床研究中脑和其他器官在卒中病理生理学中相互作用的现有证据，并讨论了这些相互作用在卒中的进展和结果中的作用，以及它们如何指导更有效的治疗策略的发展。(C)2015 Elsevier Inc.保留所有权利。
Stroke is associated with a high risk of disability and mortality, and with the exception of recombinant tissue-type plasminogen activator for acute stroke, most treatments have proven ineffective. Clinical translation of promising experimental therapeutics is limited by inadequate stroke models and a lack of understanding of the mechanisms underlying acute stroke and how they affect outcome. Bidirectional communication between the ischemic brain and peripheral immune system modulates stroke progression and tissue repair, while epidemiological studies have provided evidence of an association between organ dysfunction and stroke risk. This crosstalk can determine the fate of stroke patients and must be taken into consideration when investigating the pathophysiological mechanisms and therapeutic options for stroke. This review summarizes the current evidence for interactions between the brain and other organs in stroke pathophysiology in basic and clinic studies, and discusses the role of these interactions in the progression and outcome of stroke and how they can direct the development of more effective treatment strategies. (C) 2015 Elsevier Inc. All rights reserved.