Leveraging advances in biology to design biomaterials
Leveraging advances in biology to design biomaterials
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DOI：
10.1038/nmat4991
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发表时间：
2017-12-01
期刊：
影响因子：
41.2
通讯作者：
Mooney, David J.
中科院分区：
文献类型：
--
作者：
Darnell, Max;Mooney, David J.
生物材料的功能和复杂性显着增加，从而可以对与其相互作用的细胞进行前所未有的控制。这些工程进步带来了改进基于生物材料的疗法的前景，但实际限制有利于简单性。生物学界的工具正在实现高分辨率和高通量的生物测定，如果将其纳入生物材料设计框架中，可以帮助实现前所未有的功能，同时通过识别最重要的材料参数和生物输出来最大限度地降低设计的复杂性。然而，为了避免数据爆炸并有效地将测定的信息内容与实验目标相匹配，必须以特定的方式安排材料筛选和生物测定。通过借鉴生物过程工程界的实验和工作流程设计方法，我们概述了将下一代生物测定纳入生物材料设计的框架，以有效优化功能，同时最大限度地降低复杂性。该框架可以激发生物材料设计，最大限度地提高功能性和可翻译性。
Biomaterials have dramatically increased in functionality and complexity, allowing unprecedented control over the cells that interact with them. From these engineering advances arises the prospect of improved biomaterial-based therapies, yet practical constraints favour simplicity. Tools from the biology community are enabling high-resolution and high-throughput bioassays that, if incorporated into a biomaterial design framework, could help achieve unprecedented functionality while minimizing the complexity of designs by identifying the most important material parameters and biological outputs. However, to avoid data explosions and to effectively match the information content of an assay with the goal of the experiment, material screens and bioassays must be arranged in specific ways. By borrowing methods to design experiments and workflows from the bioprocess engineering community, we outline a framework for the incorporation of next-generation bioassays into biomaterials design to effectively optimize function while minimizing complexity. This framework can inspire biomaterials designs that maximize functionality and translatability.