Synthesis of glycolipid analogues that disrupt binding of HIV-1 gp120 to galactosylceramide.
Synthesis of glycolipid analogues that disrupt binding of HIV-1 gp120 to galactosylceramide.
复制标题
合成糖脂类似物，破坏 HIV-1 gp120 与半乳糖神经酰胺的结合。
DOI：
10.1016/s0960-894x(00)00153-0
复制
发表时间：
2000
影响因子：
2.7
通讯作者：
Ganem,B
中科院分区：
文献类型：
--
作者：
Weber,KT;Hammache,D;Fantini,J;Ganem,B
已显示HIV-1通过HIV gp 120与糖脂半乳糖基神经酰胺（1）（GalCer）的结合感染CD 4阴性细胞。制备了1的几种类似物，以研究1在膜双层中参与gp 120结合的特定取向。有趣的是，N-硬脂基-1-脱氧野尻霉素（8）对gp 120显示出与1相同的有效特异性亲和力，这一发现可能有助于阐明N-丁基-1-脱氧野尻霉素的抗病毒活性。
HIV-1 has been shown to infect CD4 negative cells by the binding of HIV gp120 to the glycolipid galactosylceramide (1) (GalCer). Several analogues of 1 were prepared to investigate the specific orientation of 1 in the membrane bilayer that is involved in gp120 binding. Interestingly, N-stearyl-1-deoxynojirimycin (8) displayed potent and specific affinity for gp120 equal to that of 1, a finding that may shed light on the antiviral activity of N-butyl-1-deoxynojirimycin.