Altered expression of E-cadherin in hepatocellular carcinoma:: Correlations with genetic alterations, β-catenin expression, and clinical features
Altered expression of E-cadherin in hepatocellular carcinoma:: Correlations with genetic alterations, β-catenin expression, and clinical features
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DOI：
10.1053/jhep.2002.35342
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发表时间：
2002-09-01
期刊：
影响因子：
13.5
通讯作者：
Buendia, MA
中科院分区：
文献类型：
--
作者：
Wei, Y;Van Nhieu, JT;Buendia, MA
E-钙粘蛋白是一种关键的细胞黏附蛋白，在人类肿瘤中作为肿瘤/侵袭抑制因子，是β-连环素的结合伙伴，在Wnt信号转导和肿瘤发生中起关键作用。在此，我们报道了E-钙粘附素和β-连环素在肝细胞癌中的遗传和表达研究。免疫组织化学。对37例肝癌及癌旁非肿瘤组织中E-钙粘蛋白表达的分析显示，不同肿瘤标本之间存在着重要的差异，从35%的完全或异质性下调到40%的肿瘤明显过表达。E-钙粘蛋白表达缺失与E-钙粘蛋白基因座杂合性缺失和启动子区域CpG岛甲基化密切相关(P
E-cadherin is a key cell adhesion protein implicated as a tumor/invasion suppressor in human carcinomas and a binding partner of beta-catenin, which plays a critical role in Wnt signaling and in tumorigenesis. Here we report genetic and expression studies of E-cadherin and beta-catenin in hepatocellular carcinoma (HCC). Immunohistochemical. analysis of E-cadherin expression in 37 HCCs and adjacent nontumor tissues revealed important variations among tumor samples, ranging from complete or heterogeneous down-regulation in 35% of cases to marked overexpression in 40% of tumors. Loss of E-cadherin expression was closely associated with loss of heterozygosity (LOH) at the E-cadherin locus and methylation of CpG islands in the promoter region (P