Evidence for in vivo Reaction of Antibody and Complement to Surface Antigens of Human Cancer Cells
Evidence for in vivo Reaction of Antibody and Complement to Surface Antigens of Human Cancer Cells
复制标题
抗体和补体与人类癌细胞表面抗原发生体内反应的证据
作者：
K. Irie;R. Irie;D. Morton
免疫粘附试验用于确定癌症患者体内的抗体和补体是否与肿瘤细胞在体内固定。从尸体解剖和活组织检查中获得的人类癌细胞，红细胞在体外粘附在其表面。进一步添加补体的C2和C3成分增强了粘附性，并通过C3抗体（即β 1c球蛋白）的初步治疗降低了粘附性。结果表明，肿瘤相关膜抗原在体内可与抗体和补体形成复合物。
The immune adherence test was used to determine whether antibody and complement in cancer patients are fixed in vivo to tumor cells. Human erythrocytes adhered in vitro to the surface of human cancer cells obtained from autopsy and biopsy. Adherence was enhanced by further addition of the C2 and C3 components of complement, and was diminished by preliminary treatment with antibody to C3 (that is, to β1C-globulin). The results suggest that tumor associated membrane antigens form complexes in vivo with antibodies and complement.