TIMING OF PEAK BONE MASS IN CAUCASIAN FEMALES AND ITS IMPLICATION FOR THE PREVENTION OF OSTEOPOROSIS - INFERENCE FROM A CROSS-SECTIONAL MODEL
TIMING OF PEAK BONE MASS IN CAUCASIAN FEMALES AND ITS IMPLICATION FOR THE PREVENTION OF OSTEOPOROSIS - INFERENCE FROM A CROSS-SECTIONAL MODEL
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DOI：
10.1172/jci117034
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发表时间：
1994-02-01
影响因子：
15.9
通讯作者：
HEANEY, RP
中科院分区：
文献类型：
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作者：
MATKOVIC, V;JELIC, T;HEANEY, RP
为了确定骨量和密度峰值的时间，我们对 265 名 8-50 岁绝经前白人女性的骨量测量进行了横断面研究。使用双X射线吸收法和单光子吸收法测量脊柱（前后、侧向）、股骨近端、桡骨干、前臂远端和全身的骨量和骨矿物质密度。使用二次回归模型和二次-二次或二次-线性形式的分段回归模型来分析骨量参数。结果表明，多个骨骼位置的大部分骨量将在青春期后期积累。这对于股骨近端和椎体的骨矿物质密度尤其值得注意。其他感兴趣区域的骨量要么在 18 岁至更年期的女性中没有差异，要么在 50 岁的女性中达到最大，这表明某些部位的骨积累缓慢但永久，持续到更年期。绝经前成年女性骨量的增加可能是骨膜随着年龄持续扩张的结果。由于所有部位的骨骼矿物质快速获取发生在生命相对较早的时期，因此需要更精确地识别和表征可能优化峰值骨量的外源因素。
To determine the timing of peak bone mass and density, we conducted a cross-sectional study of bone mass measurements in 265 premenopausal Caucasian females, aged 8-50 yr. Bone mass and bone mineral density were measured using dual X-ray absorptiometry and single-photon absorptiometry at the spine (anteroposterior, lateral), proximal femur, radius shaft, distal forearm, and the whole body. Bone mass parameters were analyzed using a quadratic regression model and segmented regression models with quadratic-quadratic or quadratic-linear form. The results show that most of the bone mass at multiple skeletal locations will be accumulated by late adolescence. This is particularly notable for bone mineral density of the proximal femur and the vertebral body. Bone mass of the other regions of interest is either no different in women between the age of 18 yr and the menopause or it is maximal in 50-yr-old women, indicating slow but permanent bone accumulation continuing at some sites up to the time of menopause. This gain in bone mass in premenopausal adult women is probably the result of continuous periosteal expansion with age. Since rapid skeletal mineral acquisition at all sites occurs relatively early in life, the exogenous factors which might optimize peak bone mass need to be more precisely identified and characterized.