Events at the transition between cell cycle exit and oligodendrocyte progenitor differentiation: the role of HDAC and YY1
Events at the transition between cell cycle exit and oligodendrocyte progenitor differentiation: the role of HDAC and YY1
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DOI：
10.1017/s1740925x08000057
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发表时间：
2007-01-01
影响因子：
--
通讯作者：
Casaccia-Bonnefil, Patrizia
中科院分区：
文献类型：
--
作者：
He, Ye;Sandoval, Juan;Casaccia-Bonnefil, Patrizia
成人大脑的复杂性是一系列发育事件的综合结果，这些事件取决于分化的适当时机。转录调控网络和基因表达调控的表观遗传机制的重要性正变得越来越明显。在这些机制中，先前的工作揭示了组蛋白去乙酰化在少突胶质细胞分化中的重要性。在这篇手稿中，我们定义了转录因子阴阳1（YY 1）和组蛋白去乙酰化酶1之间的相互作用区域，并表征YY 1过表达对少突胶质细胞祖细胞分化的功能后果。
complexity of the adult brain is the result of an integrated series of developmental events that depends on appropriate timing of differentiation. The importance of transcriptional regulatory networks and epigenetic mechanisms of regulation of gene expression is becoming increasingly evident. Among these mechanisms, previous work has revealed the importance of histone deacetylation in oligodendrocyte differentiation. In this manuscript we define the region of interaction between transcription factor Yin-Yang 1 (YY1) and histone deacetylase 1, and characterize the functional consequences of YY1 overexpression on the differentiation of oligodendrocyte progenitors.