Frontal-subcortical circuits: The anatomic basis of executive, social and motivated behaviors
Frontal-subcortical circuits: The anatomic basis of executive, social and motivated behaviors
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DOI：
10.1177/026988119701100203
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发表时间：
1997-01-01
影响因子：
4.1
通讯作者：
Cummings, JL
中科院分区：
文献类型：
--
作者：
Masterman, DL;Cummings, JL
已经证实，一系列离散的、平行的额叶-皮质下环路将额叶的特定区域与基底节和丘脑内的区域联系起来。可以描述涉及背外侧前额叶、眶前叶和前扣带回的各种回路特异性行为。在这些闭合环路内的不同级别发生的中断或不平衡被认为是所看到的特征行为模式的基础。纹状体复杂的神经化学排列和这些关键的皮质下结构中发生的复杂的神经递质相互作用构成了影响这些回路的调制影响的基础。
A series of discrete, parallel frontal-subcortical circuits have been demonstrated to link specific areas of the frontal lobe to areas within the basal ganglia and thalamus. A variety of circuit-specific behaviors can be described involving the dorsolateral prefrontal, orbitofrontal and anterior cingulate circuits. Interruptions or imbalance occurring at various levels within these closed looped circuits is felt to underlie the characteristic behavioral patterns seen. The intricate neurochemical arrangement of the striatum and the complex neurotransmitter interactions that occur within these key subcortical structures form the basis for modulatory influences that can affect these circuits.