Conversion of Dihydroartemisinic Acid into Dihydro-epi-deoxyarteannuin B
Conversion of Dihydroartemisinic Acid into Dihydro-epi-deoxyarteannuin B
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二氢青蒿酸转化为二氢表脱氧青蒿素B
DOI：
10.1002/ejoc.201500291
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发表时间：
2015
影响因子：
2.8
通讯作者：
Wu Yikang
中科院分区：
文献类型：
--
作者：
Chen Hui-Jun;Hao Hong-Dong;Wu Yikang
在系统考察了几种潜在的适用条件后，研究人员开发了一种简单、高产的一步法将二氢青蒿酸转化为二氢外皮脱氧青蒿素B的方法。二氢青蒿素B是一种天然产物，也是从马蒿属植物中分离出来的其他几种天然产物的关键化合物。Pd(OAc)2/CuCl2/MnO2最令人满意地实现了转化，使得从现成的青蒿酸中获得许多已知的有效抗疟疾三氧嘧啶成为可能。还介绍了一些羰基之间的有趣的区别。
A facile and high‐yielding one‐step conversion of dihydroartemisinic acid into dihydro‐epi‐deoxyarteannuin B, a natural product and a pivotal compound in the synthesis of several other natural products isolated fromArtemisia annua L., was developed after the systematic examination of several potentially applicable conditions. The transformation, most satisfactorily effected with Pd(OAc)2/CuCl2/MnO2, makes it possible to access many known potent antimalarial trioxanes from readily available artemisinic acid. Some interesting cases of differentiation between the carbonyl groups are also presented.