Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility
Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility
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DOI：
10.1128/aac.00349-06
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发表时间：
2006-08-01
影响因子：
4.9
通讯作者：
Edlind, Thomas
中科院分区：
文献类型：
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作者：
Katiyar, Santosh;Pfaller, Michael;Edlind, Thomas
一个公认的热点突变赋予降低棘白菌素敏感性（RES）是残基S645的白色念珠菌Gsc 1（Fks 1）。我们报告突变F641 Y与白色念珠菌分离的RES。类似的Fks 2残基突变的F到V的光滑念珠菌RES分离;引入这种突变到敏感的光滑念珠菌证实了它在RES的作用。Y 641-等效的Fks残基被确定在本质上RES镰刀菌属和季也蒙念珠菌。
A recognized hotspot for mutations conferring reduced echinocandin susceptibility (RES) is residue S645 of Candida albicans Gsc1(Fks1). We report that the mutation F641Y is associated with RES in a C albicans isolate. The analogous Fks2 residue is mutated F to V in a Candida glabrata RES isolate; the introduction of this mutation into susceptible C glabrata confirmed its role in RES. Y641-equivalent Fks residues were identified in intrinsically RES Fusarium species and Candida guilliermondii.