Translocation of an Incompressible Vesicle through a Pore.
Translocation of an Incompressible Vesicle through a Pore.
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不可压缩的囊泡通过孔隙的转移。
DOI：
10.1021/acs.jpcb.6b02079
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发表时间：
2016-07-07
期刊：
影响因子：
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通讯作者：
Muthukumar M
中科院分区：
文献类型：
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作者：
Shojaei HR;Muthukumar M
我们已经推导出的自由能景观易位的一个单一的囊泡通过一个狭窄的孔占弯曲和拉伸的囊泡，和变形的囊泡的孔。易位的自由能垒的出现是一个普遍的结果，和势垒的大小计算的各种材料参数。通过外部恒定力的存在下的障碍的减少的程度进行计算。使用Fokker-Planck形式主义，我们已经计算了对应于代表不同参数集的各种自由能景观的平均易位时间。导出了平均移位时间与外力强度、囊泡尺寸、囊泡的弯曲模量和拉伸模量以及孔的半径和长度的关系，并对计算结果进行了讨论。
We have derived the free energy landscape for the translocation of a single vesicle through a narrow pore by accounting for bending and stretching of the vesicle, and the deformation of the vesicle by the pore. Emergence of a free energy barrier for translocation is a general result, and the magnitude of the barrier is calculated in terms of the various material parameters. The extent of the reduction in the barrier by the presence of an external constant force is calculated. Using the Fokker–Planck formalism, we have calculated the average translocation time corresponding to the various free energy landscapes representing different parameter sets. The dependencies of the average translocation time on the strength of the external force, vesicle size, bending and stretching moduli of the vesicle, and radius and length of the pore are derived, and the computed results are discussed.