Vascular function and inflammation in rheumatoid arthritis: the role of physical activity.
Vascular function and inflammation in rheumatoid arthritis: the role of physical activity.
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DOI：
10.2174/1874192401004020089
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发表时间：
2010-02-23
期刊：
影响因子：
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通讯作者：
Kitas, George D
中科院分区：
文献类型：
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作者：
Metsios, George S;Stavropoulos-Kalinoglou, Antonios;Kitas, George D
炎症会干扰内皮细胞内稳态的生化途径。研究已经在炎症介质，特别是c反应蛋白和肿瘤坏死因子α、内皮功能障碍和动脉粥样硬化之间建立了明确的联系。内皮功能障碍和动脉粥样硬化在早期阶段可能是亚临床的，因此用非侵入性技术检测它们的能力至关重要，特别是在心血管疾病风险增加的人群中，如类风湿关节炎患者。这可能有助于及早发现可能逆转这些进程的干预措施。可以达到这一目的的最佳非药物干预措施之一是体育活动。本文探讨了炎症、内皮功能障碍和动脉粥样硬化之间的关系，并讨论了运动在阻断炎症、内皮功能障碍-动脉粥样硬化网络中特定通路中的作用。
Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and atherosclerosis may be subclinical at early stages, and thus the ability to detect them with non-invasive techniques is crucially important, particularly in populations at increased risk for cardiovascular disease, such as those with rheumatoid arthritis. This may allow the identification of interventions that may reverse these processes early on. One of the best non-pharmacological interventions that may achieve this is physical activity. This review explores the associations between inflammation, endothelial dysfunction, and atherosclerosis and discusses the role of exercise in blocking specific pathways in the inflammation, endothelial dysfunction - atherosclerosis network.