The potential of adiponectin in driving arthritis
The potential of adiponectin in driving arthritis
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DOI：
10.4049/jimmunol.176.7.4468
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发表时间：
2006-04-01
影响因子：
4.4
通讯作者：
Mueller-Ladner, Ulf
中科院分区：
文献类型：
--
作者：
Ehling, Angela;Schaeffler, Andreas;Mueller-Ladner, Ulf
关节脂肪组织是人类关节的普遍组成部分，但其局部功能在很大程度上是未知的。由于最近的研究揭示了脂肪组织，脂肪细胞因子和关节炎之间的联系，我们研究了脂肪细胞因子脂联素的表达及其在不同关节炎患者关节脂肪组织和滑膜中的功能作用。与其在内分泌和血管疾病中的保护作用相反，脂联素被发现参与人类关节中炎症和基质降解的关键途径。脂联素在人滑膜成纤维细胞中的作用似乎是高度选择性的，通过p38 MAPK途径仅诱导类风湿性关节炎病理生理学的两种主要介质IL-6和基质金属蛋白酶-1。由于观察到这些作用可以被不同的TNF-α抑制剂抑制，脂肪细胞因子如脂联素也可能是炎性关节疾病治疗策略的关键靶点。总之，关节脂肪组织和脂肪细胞因子在慢性炎症性疾病如关节炎中不能再被视为无辜的旁观者。
Articular adipose tissue is a ubiquitous component of human joints, but its local functions are largely unknown. Because recent studies revealed several links between adipose tissue, adipocytokines, and arthritis, we investigated the expression of the adipocytokine adiponectin and its functional role in articular adipose tissue and synovium of patients with different arthritides. In contrast to its protective role in endocrinological and vascular diseases, adiponectin was found to be involved in key pathways of inflammation and matrix degradation in the human joint. The effects of adiponectin in human synovial fibroblasts appear to be highly selective by inducing only two of the main mediators of rheumatoid arthritis pathophysiology, IL-6 and matrix metalloproteinase-1, via the p38 MAPK pathway. Owing to the observation that these effects could be inhibited by different TNF-alpha inhibitors, adipocytokines such as adiponectin may also be key targets for therapeutic strategies in inflammatory joint diseases. In summary, articular adipose tissue and adipocytokines cannot be regarded as innocent bystanders any more in chronic inflammatory diseases such as arthritis.