Three-dimensional gray matter atrophy mapping in mild cognitive impairment and mild Alzheimer disease
Three-dimensional gray matter atrophy mapping in mild cognitive impairment and mild Alzheimer disease
复制标题
DOI：
10.1001/archneur.64.10.1489
复制
发表时间：
2007-10-01
影响因子：
--
通讯作者：
Thompson, Paul M.
中科院分区：
文献类型：
--
作者：
Apostolova, Liana G.;Steiner, Calen A.;Thompson, Paul M.
背景：阿尔茨海默氏病（AD）是全球痴呆症最常见的形式。轻度认知障碍（MCI）是在没有功能下降的情况下认知缺陷患者的近期术语。大多数患有MCI的患者藏有AD的病理变化，并以每年10％至15％的速度表现出向痴呆症的过渡。 AD和MCI患者经历了进行性脑萎缩。目标：使用先进的三维皮层映射技术分析24例氨基MCI和25例轻度AD患者的结构磁共振成像数据。设计：横截面同类群设计。患者/方法：我们使用A分析了24个柔韧性MCI（平均MMSE，28.1; SD； SD，1.7）和25名轻度AD患者的结构磁共振成像数据（所有MMSE分数，> 18;平均MMSE，23.7; SD，2.9）高级三维皮层图技术。种子：我们观察到轻度AD患者的皮质萎缩明显更大。内嗅皮层，比左侧颞皮层，右顶叶皮层和双侧前皮层的右侧皮层多于萎缩15％，其余的皮质主要在轻度AD患者中主要表现出10％至15％的萎缩。 。判定：轻度AD与紧邻MCI的认知状态之间存在明显的皮质差异。疾病过程中早期影响的皮质区域比晚期受影响的皮质区域受到严重影响。我们的方法可能被证明是一种可靠的体内疾病跟踪技术，也可以用于评估未来调整疾病的疗法。
Background: Alzheimer disease ( AD) is the most common form of dementia worldwide. Mild cognitive impairment (MCI) is the recent terminology for patients with cognitive deficiencies in the absence of functional decline. Most patients with MCI harbor the pathologic changes of AD and demonstrate transition to dementia at a rate of 10% to 15% per year. Patients with AD and MCI experience progressive brain atrophy.Objective: To analyze the structural magnetic resonance imaging data for 24 patients with amnestic MCI and 25 patients with mild AD using an advanced 3-dimensional cortical mapping technique.Design: Cross-sectional cohort design.Patients/Methods: We analyzed the structural magnetic resonance imaging data of 24 amnestic MCI ( mean MMSE, 28.1; SD, 1.7) and 25 mild AD patients (all MMSE scores, > 18; mean MMSE, 23.7; SD, 2.9) using an advanced 3-dimensional cortical mapping technique.Results: We observed significantly greater cortical atrophy in patients with mild AD. The entorhinal cortex, right more than left lateral temporal cortex, right parietal cortex, and bilateral precuneus showed 15% more atrophy and the remainder of the cortex primarily exhibited 10% to 15% more atrophy in patients with mild AD than in patients with amnestic MCI.Conclusion: There are striking cortical differences between mild AD and the immediately preceding cognitive state of amnestic MCI. Cortical areas affected earlier in the disease process are more severely affected than those that are affected late. Our method may prove to be a reliable in vivo disease-tracking technique that can also be used for evaluating disease-modifying therapies in the future.