HEAVY WATER SLOWS BIOLOGICAL TIMING PROCESSES
HEAVY WATER SLOWS BIOLOGICAL TIMING PROCESSES
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DOI：
10.1007/bf00299200
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发表时间：
1971-01-01
期刊：
影响因子：
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通讯作者：
ENRIGHT, JT
中科院分区：
文献类型：
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作者：
ENRIGHT, JT
氧化氢延长了沙滩等足类的内源性潮汐活动节律的周期。重水也被证明在鹿鼠的饮用水中加入时，会延缓鹿鼠的昼夜节律。对于等足类动物和小鼠，这种效应的平均剂量依赖关系都可以高精度地估计出来，而且这两个值是无法区分的。据报道，由于D2O，一种藻类、一种高等植物、两种鸟类和其他三种啮齿动物也出现了类似的昼夜节律放缓。虽然对于后一种情况，还没有发表可靠的剂量依赖估计数据，但这种影响显然也是相同的。这一证据表明，在节奏机制上存在根本的相似之处。重水还使几种生物节律可逆地减慢，其周期在毫秒范围内：裸子鱼(Stenarchus Albirons)的电子器官放电；金鱼以及端足类(Paraphoxus)和等足类(Exciroll Ana)的呼吸周期；文蛤(Donax)和螃蟹(Emerita)的心跳周期。由于这些高频节律起源于依赖于扩散过程的起搏器，实验结果表明，长周期生物钟也可能是基于扩散依赖的起搏器。
Deuterium oxide lengthens the period of the endogenous tidal activity rhythm of the sand-beach isopod,Excirolana chiltoni. Heavy water has also been shown to retard the circadian rhythm of deer mice, when added to the animals' drinking water. The average dosage dependence of the effect can be estimated with high precision for both isopod and mouse, and the two values are indistinguishable. A similar slowing of circadian rhythms, due to D2O, has also been reported for an alga, a higher plant, two species of birds and three other rodents. Although data permitting reliable estimates of dosage dependence have not been published for these latter cases, the effect is apparently also of about the same magnitude. This evidence suggests fundamental similarities in the rhythmic mechanisms. Heavy water also produces a reversible slowing of several biological rhythms with periods in the millisecond range: the electric-organ discharge of a gymnotid fish (Stenarchus albifrons); the respiratory cycle of goldfish, as well as of an amphipod (Paraphoxus) and an isopod (Excirolana); and the cardiac cycle of a clam (Donax) and a crab (Emerita). Since these high-frequency rhythms originate in pacemakers dependent on diffusion processes, the experimental results suggest the possibility that long-period biological clocks are also based on diffusion-dependent pacemakers.