Amidine Sulfonamides and Benzene Sulfonamides: Synthesis and Their Biological Evaluation
Amidine Sulfonamides and Benzene Sulfonamides: Synthesis and Their Biological Evaluation
复制标题
DOI：
10.1155/2015/524056
复制
发表时间：
2015-01-01
影响因子：
3
通讯作者：
Shafiq, Muhammad Imtiaz
中科院分区：
文献类型：
--
作者：
Qadir, Muhammad Abdul;Ahmed, Mahmood;Shafiq, Muhammad Imtiaz
Newamidine and benzene sulfonamide derivatives were developed and structures of the new products were confirmed by elemental and spectral analysis (FT-IR, ESI-MS, (HNMR)-H-1, and (CNMR)-C-13). In vitro, developed compounds were screened for their antibacterial and antifungal activities against medically important bacterial strains, namely, S. aureus, B. subtilis, and E. coli, and fungi, namely, A. flavus, A. parasiticus, and A. sp. The antibacterial and antifungal activities have been determined by measuring MIC values (mu g/mL) and zone of inhibitions (mm). Among the tested compounds, it was found that compounds 3b, 9a, and 9b have most potent activity against S. aureus, A. flavus, and A. parasiticus, respectively, and were found to be more active than sulfamethoxazole and itraconazole with MIC values 40 mu g/mL. In contrast, all the compounds were totally inactive against the A. sp. except 10b and 15b to show activity to some extent.
