Attenuation of brain BOLD response following lipid ingestion
Attenuation of brain BOLD response following lipid ingestion
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DOI：
10.1002/hbm.10131
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发表时间：
2003-10-01
影响因子：
4.8
通讯作者：
Bells, S
中科院分区：
文献类型：
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作者：
Noseworthy, MD;Alfonsi, J;Bells, S
功能磁共振成像数据存在着很大的异质性。即使在同一受试者中，连续几天或扫描会话的结果通常在显著激活的像素的数量和/或激活的强度上不同。我们试图评估可控的生理调节剂（例如饮食因素）是否会影响fMRI数据的结果。例如，在功能性磁共振成像扫描之前，高脂肪饮食可以改变微血管血液流变学因素，并可能改变脑血氧水平依赖（BOLD）信号模式。在健康的成年志愿者中，我们在空腹状态下双侧手指敲击（2 Hz）期间以及在摄入235 mL Ensure Plus（Ross Labs）单独或补充25 cc或50 cc菜籽油后40分钟和100分钟时测量了大脑BOLD信号。25 cc和50 cc芥花油治疗均在餐后40和100分钟产生BOLD信号的显著双侧降低。在不存在油的情况下，使用Ensure未观察到显著影响。因此，为了减少受试者内和受试者之间的fMRI异质性，从而增加fMRI统计功效，建议应避免在高脂肪摄入后2小时内进行扫描。作为一个必然的结果，一个受试者的生理状态的透彻理解，功能磁共振成像检查之前，可能会减少其他混杂变量的影响。(C)2003 Wiley-Liss，Inc.
A great deal of heterogeneity exists in fMRI data. Even within the same subject, results on successive days or scan sessions often differ in the number of significantly, activated pixels and/or the intensity of activation. We sought to assess whether controllable physiologic modulators, such as dietary factors, could influence the outcome of fMRI data. A high fat diet, for example,prior to a fMRI scan could change microvascular blood rheologic factors and potentially alter brain blood oxygen-level dependent (BOLD) signal patterns. In healthy adult volunteers, we measured brain BOLD signal during bilateral finger tapping (2 Hz) in the fasted state, and at 40 and 100 minutes post-ingestion of a 235 mL can of Ensure Plus (Ross Labs), alone or supplemented with either 25cc or 50cc of canola oil. Both the 25cc and 50cc Canola oil treatments produced a significant bilateral decrease in BOLD signal 40 and 100 minutes postprandial. No significant effect was observed with Ensure in the absence of oil. Therefore, to decrease fMRI within and between subject heterogeneity, and thereby increase fMRI statistical power, it is suggested that scanning within 2 hours post high fat ingestion should be avoided. As a corollary, a thorough understanding of a subject's physiological state, prior to an fMRI exam, may reduce the impact of other confounding variables. (C) 2003 Wiley-Liss, Inc.