Pharyngoglottal closure reflex: identification and characterization in a feline model
Pharyngoglottal closure reflex: identification and characterization in a feline model
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DOI：
10.1152/ajpgi.1998.275.3.g521
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发表时间：
1998-09-01
影响因子：
4.5
通讯作者：
Lang, IM
中科院分区：
文献类型：
--
作者：
Shaker, R;Medda, BK;Lang, IM
早期对人类的研究表明，在阈值容量下用水刺激咽部会引起短暂的声带内收，即咽声门闭合反射。本研究的目的是：1)建立适合于该反射生理研究的动物模型；2)描述该反射的神经通路和效应器官。猫的研究是通过同时进行视频内窥镜和测压，然后进行肌电研究完成的。在阈值容量(0.3+/-0.06毫升)下，咽内注水可导致声带短暂闭合，并使气管插口闭合。S平均闭合时间为1.1±0.1d，切断双侧舌咽神经可完全消除咽水刺激引起的这种反射，但不能完全消除咽水刺激引起的吞咽反应。猫存在咽声门闭合反射。舌咽神经是这一反射的传入通路，其靶器官包括鳗间肌和环鳗外侧肌。
Earlier studies in humans have shown that pharyngeal stimulation by water at a threshold volume induces a brief vocal cord adduction, i.e., pharyngoglottal closure reflex. The present study was undertaken to 1) develop a suitable animal model for physiological studies of this reflex and 2) delineate its neural pathway and effector organs. Studies were done in cats by concurrent videoendoscopy and manometry followed by electromyographic studies. At a threshold volume (0.3 +/- 0.06 ml), injection of water into the pharynx resulted in a brief closure of the vocal folds, closing the introitus to the trachea. Duration of this closure averaged 1.1 +/- 0.1 s. Bilateral transection of the glossopharyngeal nerve completely abolished this reflex but not swallows induced by pharyngeal water stimulation. The pharyngoglottal closure reflex is present in the cats. The glossopharyngeal nerve is the afferent pathway of this reflex, and the interarytenoid and lateral cricoarytenoid muscles are among its target organs.