Nickel-catalyzed cyanation reaction of aryl/alkenyl halides with alkyl isocyanides.
Nickel-catalyzed cyanation reaction of aryl/alkenyl halides with alkyl isocyanides.
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DOI：
10.1039/d2ob01240e
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Bingwei Zhou
中科院分区：
文献类型：
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作者：
Yanling Zhang;Zhiguo Zhang;Yuanyuan Hu;Yunkui Liu;Hongwei Jin;Bingwei Zhou
We herein describe a nickel-catalyzed cyanation reaction of aryl/alkenyl halides with alkyl isocyanides. Both aryl/alkenyl iodines and bromides were found to be competent electrophiles that reacted with alkyl isocyanides, affording nitrile compounds in moderate to good yields. A range of functional groups including halogens as well as hydroxyl, formyl, and acetamino groups were fairly compatible with the nickel catalysis. This protocol featured broad functional group tolerance, simple reaction conditions, and gram-scale synthesis.
