Molecular basis for resistance to the anticancer drug cisplatin in Dictyostelium.
Molecular basis for resistance to the anticancer drug cisplatin in Dictyostelium.
复制标题
盘基网柄菌对抗癌药物顺铂耐药的分子基础。
DOI：
10.1099/00221287-146-9-2219
复制
发表时间：
2000
期刊：
影响因子：
1.5
通讯作者：
S. Alexander
中科院分区：
文献类型：
--
作者：
Guochun Li;Hannah Alexander;Natalie Schneider;S. Alexander
The efficacy of the widely used chemotherapeutic drug cisplatin is limited by the occurrence of drug-resistant tumour cells. To fully exploit the potential of this drug in cancer therapy, it is imperative to understand the molecular basis of cisplatin resistance. Using an insertional mutagenesis technique in cells of Dictyostelium discoideum, we have identified six genes which are involved in cisplatin resistance. None of these genes has been previously linked to resistance to this drug. Several of these genes encode proteins that are involved in signal transduction pathways which regulate cell death, cell proliferation or gene regulation. The resistance of these mutant strains is specific for cisplatin, since deletion of these genes does not confer resistance to other DNA-damaging agents. Significantly, the disruption of three of these genes, encoding the sphingosine-1-phosphate lyase, the RegA cAMP phosphodiesterase and a phosphatidylinositol-4-phosphate 5-kinase, also results in abnormalities in the multicellular development of this organism, although there is no change in the rate of mitotic cell growth. This study has identified previously unsuspected molecular pathways which function in the cellular response to cisplatin and are required for normal morphogenesis, and underscores the complexity of the cellular response to cisplatin. These pathways provide potential targets for modulating the response to this important drug.
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DOI：
10.1016/0065-2571(95)00005-4
发表时间：
1996-01-01
期刊：
ADVANCES IN ENZYME REGULATION, VOL 36
影响因子：
--
作者：
Loijens, JC;Boronenkov, IV;Anderson, RA
通讯作者：
Anderson, RA
影响因子：
2.9
作者：
EASTMAN, A
通讯作者：
EASTMAN, A
cAMP-磷酸二酯酶控制 PKA 依赖性分化。
DOI：
10.1242/dev.125.4.691
发表时间：
1998
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Shaulsky,G;Fuller,D;Loomis,WF
通讯作者：
Loomis,WF
酿酒酵母 cAMP 依赖性蛋白激酶突变体对顺铂的敏感性。
DOI：
--
发表时间：
1998
期刊：
Anticancer research.
影响因子：
--
作者：
Cvijic,ME;Yang,WL;Chin,KV
通讯作者：
Chin,KV
影响因子：
5.5
作者：
Spiegel, S
通讯作者：
Spiegel, S