A review on the mechanism of iodide metabolic dysfunction in differentiated thyroid cancer
A review on the mechanism of iodide metabolic dysfunction in differentiated thyroid cancer
复制标题
分化型甲状腺癌碘代谢异常机制研究进展
DOI：
10.1016/j.mce.2018.09.002
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发表时间：
2019-01
影响因子：
4.1
通讯作者：
Yi Heqing
中科院分区：
文献类型：
--
作者：
Zhao Yinlong;Zhong Lili;Yi Heqing
分化型甲状腺癌（DTC）的发病率在全球范围内迅速增加，其危险因素尚不清楚。随着DTC患者的不断增多，相关问题逐渐凸显，131碘（131I）是DTC的重要治疗手段，具有降低复发风险的潜力，也是治疗甲状腺癌远处转移的有效手段。然而，转移灶的碘代谢障碍使患者失去了131I治疗的机会。本文就DTC细胞碘代谢障碍的相关机制及临床转化进展作一综述。
The incidence of differentiated thyroid cancer (DTC) has been increasing rapidly worldwide, and the risk factors remain unclear. With the growing number of patients with DTC, the related issues have been gradually highlighted.131Iodide (131I) is an important treatment for DTC and has the potential to reduce the risk of recurrence.131I is also an effective treatment for distant metastases of thyroid carcinoma. However, iodide metabolism dysfunction in metastatic foci causes patients to lose the opportunity of131I treatment. This article reviews the related mechanisms of iodide metabolism dysfunction in DTC cells and summarizes the clinical transformation progression.
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影响因子：
3.9
作者：
Wächter S;Damanakis AI;Elxnat M;Roth S;Wunderlich A;Verburg FA;Fellinger SA;Bartsch DK;Di Fazio P
通讯作者：
Di Fazio P
影响因子：
5.8
作者：
Durante, C.;Haddy, N.;Schlumberger, M.
通讯作者：
Schlumberger, M.
影响因子：
4.4
作者：
G. Tong;K. Mody;Zhuo-cai Wang;D. Hamele-Bena;M. Nikiforova;Y. Nikiforov
通讯作者：
G. Tong;K. Mody;Zhuo-cai Wang;D. Hamele-Bena;M. Nikiforova;Y. Nikiforov
B-RAFV600E通过调节DNA甲基转移酶1抑制碘化钠的表达。
影响因子：
12.8
作者：
Choi, Yong Won;Kim, Hyun-Ju;Kim, Young Hwa;Park, So Hyun;Chwae, Yong Jun;Lee, Jeonghun;Soh, Euy Young;Kim, Jang-Hee;Park, Tae Jun
通讯作者：
Park, Tae Jun
影响因子：
64.5
作者：
Cancer Genome Atlas Research Network
通讯作者：
Cancer Genome Atlas Research Network