Keys to staying sharp: A randomized clinical trial of piano training among older adults with and without mild cognitive impairment.
Keys to staying sharp: A randomized clinical trial of piano training among older adults with and without mild cognitive impairment.
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保持敏锐的关键：对有或没有轻度认知障碍的老年人进行钢琴训练的随机临床试验。
DOI：
10.1016/j.cct.2019.06.003
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发表时间：
2019
影响因子：
2.2
通讯作者：
Edwards,JerriD
中科院分区：
文献类型：
--
作者：
Hudak,ElizabethM;Bugos,Jennifer;Andel,Ross;Lister,JenniferJ;Ji,Ming;Edwards,JerriD
背景痴呆症是最昂贵的医疗状况（Kirschstein，2000和Hurd等，2013 [1，2]），其前身轻度认知障碍（MCI）正在增加[3]。寻找有效的干预策略来预防或延迟痴呆症对公共卫生至关重要。先前的研究提供了令人信服的证据表明，中枢听觉处理（CAP）缺陷是痴呆症的风险因素[4-6]。基于信息退化理论[7，8]，我们假设在早期感知水平（即，CAP）可能是最佳的，以减轻认知和功能下降，并可能遏制痴呆症的患病率。钢琴训练是通过促进CAP在初始感知阶段[14-18]来增强认知的一种途径[9-13]。ObjectivesThe Keys To Staying Sharp研究是一项双臂随机临床试验，旨在研究钢琴训练相对于音乐听力指导在改善老年人CAP，认知和日常功能方面的功效。此外，调节作用的MCI状态对钢琴训练的效果将被检查和潜在的介质的干预effects. HypothesWe假设，钢琴训练将提高CAP和认知性能，导致功能的改善。我们预计，增强CAP将介导认知增益。我们进一步假设，认知收益将介导功能improvement.MethodWe计划招募360名成年人年龄60岁及以上的人将被随机钢琴训练或积极控制条件的音乐听指令和完成前和立即后评估CAP，认知和日常功能。
BackgroundThe prevalence of dementia, the most expensive medical condition (Kirschstein, 2000 and Hurd et al., 2013 [1,2]), and its precursor, mild cognitive impairment (MCI) are increasing [3]. Finding effective intervention strategies to prevent or delay dementia is imperative to public health. Prior research provides compelling evidence that central auditory processing (CAP) deficits are a risk factor for dementia [4–6]. Grounded in the information degradation theory [7, 8], we hypothesize that improving brain function at early perceptual levels (i.e., CAP) may be optimal to attenuate cognitive and functional decline and potentially curb dementia prevalence. Piano training is one avenue to enhance cognition [9–13] by facilitating CAP at initial perceptual stages [14–18].ObjectivesThe Keys To Staying Sharp study is a two arm, randomized clinical trial examining the efficacy of piano training relative to music listening instruction to improve CAP, cognition, and everyday function among older adults. In addition, the moderating effects of MCI status on piano training efficacy will be examined and potential mediators of intervention effects will be explored.HypothesesWe hypothesize that piano training will improve CAP and cognitive performance, leading to functional improvements. We expect that enhanced CAP will mediate cognitive gains. We further hypothesize that cognitive gains will mediate functional improvements.MethodWe plan to enroll 360 adults aged 60 years and older who will be randomized to piano training or an active control condition of music listening instruction and complete pre- and immediate post- assessments of CAP, cognition, and everyday function.