Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice
Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice
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DOI：
10.1523/jneurosci.3002-17.2018
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发表时间：
2018-04-11
影响因子：
5.3
通讯作者：
Senaris, Rosa
中科院分区：
文献类型：
--
作者：
Reimundez, Alfonso;Fernandez-Pena, Carlos;Senaris, Rosa
能量稳态与温度调节的耦合对于在变化的外部环境中维持恒温至关重要。我们研究了低温感受器TRPM8在两性小鼠中这种相互作用中的作用。我们证明了TRPM8是应对寒冷、喂养和禁食的精确体温调节所必需的。Trpm8（-/-）小鼠在低温环境中表现出0.7摄氏度的核心体温下降和深度低温(
The coupling of energy homeostasis to thermoregulation is essential to maintain homeothermy in changing external environments. We studied the role of the cold thermoreceptor TRPM8 in this interplay in mice of both sexes. We demonstrate that TRPM8 is required for a precise thermoregulation in response to cold, in fed and fasting. Trpm8(-/-) mice exhibited a fall of 0.7 degrees C in core body temperature when housed at cold temperatures, and a deep hypothermia (