Atrazine is an immune disruptor in adult northern leopard frogs (Rana pipiens)
Atrazine is an immune disruptor in adult northern leopard frogs (Rana pipiens)
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DOI：
10.1897/05-469.1
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发表时间：
2007-01-01
影响因子：
4.1
通讯作者：
Vatnick, Itzick
中科院分区：
文献类型：
--
作者：
Brodkin, Marc A.;Madhoun, Hareth;Vatnick, Itzick
阿特拉津是美国使用最广泛的除草剂，几项研究表明，它会干扰成年青蛙的内分泌。这项研究的结果表明，阿特拉津对青蛙也有免疫干扰作用。如我们先前所示，暴露于阿特拉嗪（21 ppb，持续8天）影响成年库蚊的先天免疫反应的方式与酸暴露（pH 5.5）相似。阿特拉津暴露抑制了巯基乙酸酯刺激的白细胞向腹腔募集至背景（林格暴露）水平，并降低了这些细胞的吞噬活性。与酸接触不同，阿特拉津接触不会导致死亡。我们的结果来自一项剂量反应研究。表明阿特拉津在破坏内分泌系统的有效剂量相同的情况下作为免疫干扰物。
Atrazine, the most widely used herbicide in the United States, has been shown in several studies to be an endocrine disruptor in adult frogs. Results from this study indicate that atrazine also functions as an immune disrupter in frogs. Exposure to atrazine (21 ppb for 8 d) affects the innate immune response of adult Rana pipiens in similar ways to acid exposure (pH 5.5), as we have previously shown. Atrazine exposure suppressed the thioglycollate-stimulated recruitment of white blood cells to the peritoneal cavity to background (Ringer exposed) levels and also decreased the phagocytic activity of these cells. Unlike acid exposure, atrazine exposure did not cause mortality. Our results, from a dose-response study. indicate that atrazine acts as an immune disruptor at the same effective doses that it disrupts the endocrine system.