Fluvastatin Attenuates Diabetes-Induced Cardiac Sympathetic Neuropathy in Association With a Decrease in Oxidative Stress
Fluvastatin Attenuates Diabetes-Induced Cardiac Sympathetic Neuropathy in Association With a Decrease in Oxidative Stress
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DOI：
10.1253/circj.cj-09-0402
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发表时间：
2010-03-01
影响因子：
3.3
通讯作者：
Inoue, Hiroshi
中科院分区：
文献类型：
--
作者：
Matsuki, Akira;Nozawa, Takashi;Inoue, Hiroshi
Background: Increased oxidative stress might contribute to diabetic (DM) neuropathy, so the effects of long-term treatment with fluvastatin (FL) on myocardial oxidative stress and cardiac sympathetic neural function were investigated in diabetic rats.Methods and Results: FL (10mg.kg(-1.)day(-1), DM-FL) or vehicle (DM-VE) was orally administered for 2 weeks to streptozotocin-induced DM rats. Cardiac oxidative stress was determined by myocardial 8-iso-prostaglandin F-2 alpha (PGF(2 alpha)) and NADPH oxidase subunit p22(phox) mRNA expression. Sympathetic neural function was quantified by autoradiography using I-131- and I-125-metaiodobenzylguanidine (MIBG). FL did not affect plasma glucose levels but remarkably decreased PGF(2 alpha) levels compared with DM-VE rats (13.8 +/- 9.2 vs 175.0 +/- 93.9ng/g tissue), although PGF(2 alpha) levels were below the detection limit in non-DM rats. FL significantly reduced myocardial p22(phox) mRNA expression. Cardiac I-131-MIBG uptake was lower in DM-VE rats than in non-DM rats, but the decrease was attenuated in DM-FL rats (1.31 +/- 0.08, 1.88 +/- 0.22, and 1.58 +/- 0.18 %kg dose/g, respectively, P
