Human Retrosplenial Cortex Displays Transient Theta Phase Locking with Medial Temporal Cortex Prior to Activation during Autobiographical Memory Retrieval
Human Retrosplenial Cortex Displays Transient Theta Phase Locking with Medial Temporal Cortex Prior to Activation during Autobiographical Memory Retrieval
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DOI：
10.1523/jneurosci.0513-13.2013
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发表时间：
2013-06-19
影响因子：
5.3
通讯作者：
Parvizi, Josef
中科院分区：
文献类型：
--
作者：
Foster, Brett L.;Kaveh, Anthony;Parvizi, Josef
压后皮质（RSC）参与人类自传体记忆提取已被脑功能成像研究证实，并得到解剖学证据的支持，RSC和内侧颞叶（MTL）内的记忆结构之间的强连接。然而，RSC及其与MTL的相互作用的电生理学研究大多仍然局限于啮齿动物的大脑。最近，我们报告了一个选择性增加的高频宽带（HFB; 70-180 Hz）的功率在人类RSC在自传体检索，和一个优势的3-5 Hz θ波段振荡在RSC在休息状态。在本研究中，我们的目的是探讨在自传体检索过程中人类RSC和MTL之间的theta波段相互作用的时间动力学。为了这个目的，我们获得了同时记录RSC和MTL在人类受试者进行侵入性电生理监测，并量化的强度RSC-MTL θ波段相位锁定。我们观察到显着的相位锁定在3- 4 Hz θ范围之间的RSC和MTL在自传体检索。这种θ波段相位耦合是短暂的，并且在受试者之间RSC HFB功率峰值之前的一致潜伏期达到峰值。对照分析证实，对于研究的其他条件、其他记录部位或其他感兴趣的频率范围（1-20 Hz），未观察到RSC和MTL之间的θ相位耦合。我们的研究结果提供了第一个证据θ波段之间的相互作用的人类RSC和MTL条件下的自传体检索。
The involvement of retrosplenial cortex (RSC) in human autobiographical memory retrieval has been confirmed by functional brain imaging studies, and is supported by anatomical evidence of strong connectivity between the RSC and memory structures within the medial temporal lobe (MTL). However, electrophysiological investigations of the RSC and its interaction with the MTL have mostly remained limited to the rodent brain. Recently, we reported a selective increase of high-frequency broadband (HFB; 70-180 Hz) power within the human RSC during autobiographical retrieval, and a predominance of 3-5 Hz theta band oscillations within the RSC during the resting state. In the current study, we aimed to explore the temporal dynamics of theta band interaction between human RSC and MTL during autobiographical retrieval. Toward this aim, we obtained simultaneous recordings from the RSC and MTL in human subjects undergoing invasive electrophysiological monitoring, and quantified the strength of RSC-MTL theta band phase locking. We observed significant phase locking in the 3-4Hz theta range between the RSC and the MTL during autobiographical retrieval. This theta band phase coupling was transient and peaked at a consistent latency before the peak of RSC HFB power across subjects. Control analyses confirmed that theta phase coupling between the RSC and MTL was not seen for other conditions studied, other sites of recording, or other frequency ranges of interest (1-20 Hz). Our findings provide the first evidence of theta band interaction between the human RSC and MTL during conditions of autobiographical retrieval.