A postsleep decline in auditory evoked potential amplitude reflects sleep homeostasis
A postsleep decline in auditory evoked potential amplitude reflects sleep homeostasis
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DOI：
10.1016/j.clinph.2011.01.041
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发表时间：
2011-08-01
影响因子：
4.7
通讯作者：
Tononi, Giulio
中科院分区：
文献类型：
--
作者：
Hulse, Brad K.;Landsness, Eric C.;Tononi, Giulio
目的：据推测，慢波活动是一种公认的睡眠稳态指标，在醒来后增加，在睡眠后减少，可能反映了皮质突触强度的变化。如果是这样，感觉诱发反应的幅度也应该随着清醒和睡眠时间的变化而变化，从而反映睡眠稳态。方法：对 12 名受试者使用 256 通道高密度脑电图 (EEG)，收集睡眠前后清醒期间的听觉诱发电位 (AEP) 和自发觉醒数据。结果：一夜睡眠后，AEP 的 N1 和 P2 波的幅度降低。此外，N1 幅度的下降与非快速眼动睡眠和自发觉醒期间的低频 EEG 功率相关，这两种睡眠需求的稳态调节指标。结论：一夜睡眠后 AEP 幅度的下降可能反映了突触强度的稳态下降。意义：这些发现为突触可塑性和睡眠稳态之间的联系提供了进一步的证据。 (C) 2011 年国际临床神经生理学联合会。由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Objective: It has been hypothesized that slow wave activity, a well established measure of sleep homeostasis that increases after waking and decreases after sleep, may reflect changes in cortical synaptic strength. If so, the amplitude of sensory evoked responses should also vary as a function of time awake and asleep in a way that reflects sleep homeostasis.Methods: Using 256-channel, high-density electroencephalography (EEG) in 12 subjects, auditory evoked potentials (AEP) and spontaneous waking data were collected during wakefulness before and after sleep.Results: The amplitudes of the N1 and P2 waves of the AEP were reduced after a night of sleep. In addition, the decline in N1 amplitude correlated with low-frequency EEG power during non-rapid eye movement sleep and spontaneous wakefulness, both homeostatically regulated measures of sleep need.Conclusions: The decline in AEP amplitude after a night of sleep may reflect a homeostatic reduction in synaptic strength. Significance: These findings provide further evidence for a connection between synaptic plasticity and sleep homeostasis. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.