Application of artificial liver in immune-related liver injury induced by immune checkpoint inhibitor: Case reports and review of the literature
Application of artificial liver in immune-related liver injury induced by immune checkpoint inhibitor: Case reports and review of the literature
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DOI：
10.3389/fimmu.2022.1001823
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发表时间：
2022
影响因子：
7.3
通讯作者：
Wenhui Yang
中科院分区：
文献类型：
--
作者：
Xuewei Li;Lina Ji;Xiaofang Li;Dong Sun;Wenhui Yang
The use of immune checkpoint inhibitors (ICIs) can improve survival of patients with malignant tumors, however, the ICI treatment is associated with unpredictable toxicity as immune-related adverse effects (irAEs). Here we report two cases of metastatic malignant gastrointestinal tumors where severe immune-mediated hepatotoxicity (IMH) developed, characterized by liver failure, after the ICI therapy. Through a strong immunosuppressive treatment and a non-biological artificial liver and supportive treatment, the liver function was restored in both cases, and the anti-tumor treatment effect was guaranteed. These results showed that the non-biological artificial liver could be capable of improve prognosis during the ICI therapy.
