Mapping the early cortical folding process in the preterm newborn brain
Mapping the early cortical folding process in the preterm newborn brain
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DOI：
10.1093/cercor/bhm180
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发表时间：
2008-06-01
期刊：
影响因子：
3.7
通讯作者：
Hueppi, P. S.
中科院分区：
文献类型：
--
作者：
Dubois, J.;Benders, M.;Hueppi, P. S.
在发育中的人类大脑中，皮质沟的形成是一个复杂的过程，从妊娠 14 周开始。由于缺乏体内早期折叠的可靠量化，人们对潜在机制（遗传、表观遗传、机械或环境）的潜在影响仍然知之甚少。在这项研究中，我们通过对出生后不久在人类皮质成熟关键发育时期（26-36 周龄）采集的磁共振图像应用专用后处理工具，以无创方式研究了 35 名早产新生儿的脑沟出现情况。通过对发育中皮层和白质之间界面的原始三维重建以及与体积测量的相关性，我们记录了体内早期的开沟，并量化了随年龄、性别和小白质病变的存在而发生的变化。我们观察到，与男性相比，女性的皮层表面较低，皮层较小，白质体积较小，但沟沟数量相当。通过精确绘制颞沟，我们强调了时间外观和半球间不对称性的个体差异，右侧颞上沟比左侧更大。因此，这种方法，包括在纵向随访中，可以提供关于皮质功能特化的结构基础以及遗传和环境因素引起的异常的早期指标。
In the developing human brain, the cortical sulci formation is a complex process starting from 14 weeks of gestation onward. The potential influence of underlying mechanisms (genetic, epigenetic, mechanical or environmental) is still poorly understood, because reliable quantification in vivo of the early folding is lacking. In this study, we investigate the sulcal emergence noninvasively in 35 preterm newborns, by applying dedicated postprocessing tools to magnetic resonance images acquired shortly after birth over a developmental period critical for the human cortex maturation (26-36 weeks of age). Through the original three-dimensional reconstruction of the interface between developing cortex and white matter and correlation with volumetric measurements, we document early sulcation in vivo, and quantify changes with age, gender, and the presence of small white matter lesions. We observe a trend towards lower cortical surface, smaller cortex, and white matter volumes, but equivalent sulcation in females compared with males. By precisely mapping the sulci, we highlight interindividual variability in time appearance and interhemispherical asymmetries, with a larger right superior temporal sulcus than the left. Thus, such an approach, included in a longitudinal follow-up, may provide early indicators on the structural basis of cortical functional specialization and abnormalities induced by genetic and environmental factors.