Regular walking breaks prevent the decline in cerebral blood flow associated with prolonged sitting
Regular walking breaks prevent the decline in cerebral blood flow associated with prolonged sitting
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DOI：
10.1152/japplphysiol.00310.2018
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发表时间：
2018-09-01
影响因子：
3.3
通讯作者：
Hopkins, Nicola D.
中科院分区：
文献类型：
--
作者：
Carter, Sophie E.;Draijer, Richard;Hopkins, Nicola D.
脑血管血流量和功能减少与认知功能降低和神经退行性疾病风险增加有关。长时间坐着会损害外周血流量和功能，但其对脑血管系统的影响尚不清楚。本研究探讨了不间断坐着和打破坐着时间对健康办公桌工作者脑血管血流量和功能的影响。 15 名参与者（10 名男性，35.8 +/- 10.2 岁，体重指数：25.5 +/- 3.2 kg/m(2)）在不同的日子以随机顺序完成了 3 个 4 小时条件：1）不间断静坐 (SIT)，2) 每 30 分钟静坐 2 分钟轻强度步行休息 (2WALK)，或 3) 静坐 8 分钟每 2 小时休息一次轻强度步行 (8WALK)。在基线和4小时，分别使用经颅多普勒（TCD）和双功超声测量大脑中动脉血流速度（MCAv）和MCA和颈动脉的CO2反应性（CVR）。使用蹲立方案通过 TCD 评估大脑自动调节 (CA)，并进行分析以生成极低、低频和高频的增益和相位值。与 2WALK（0.6 +/- 1.5 cm/s，P = 0.02）相比，SIT MCAv 显着下降（- 3.2 +/- 1.2 cm/s），但 SIT 和 8WALK 之间没有显着下降（- 1.2 +/- 1.0 cm/s，P = 0.14）。对于 CA，2WALK 极低频相位的变化（4.47 +/- 4.07 度）显着大于 SIT（- 3.38 +/- 2.82 度，P = 0.02）。 MCA 或颈动脉 CVR 无显着变化（P > 0.05）。结果表明，健康的办公桌工作者长时间不间断地坐着会减少脑血流量；然而，如果结合频繁的短时间步行休息，这种情况就会被抵消。 新与值得注意 健康的办公桌工作者长时间不间断地坐着会减少脑血流量。然而，当在坐姿期间加入频繁的短时间步行休息时，脑血流量的减少就会被抵消。对于那些长期久坐的人来说，通过频繁的积极休息策略来长期打破这些久坐的时间可能对脑血管健康产生重要影响。然而，进一步的研究应该探索这个假设。
Decreased cerebrovascular blood flow and function are associated with lower cognitive functioning and increased risk of neurodegenerative diseases. Prolonged sitting impairs peripheral blood flow and function, but its effects on the cerebrovasculature are unknown. This study explored the effect of uninterrupted sitting and breaking up sitting time on cerebrovascular blood flow and function of healthy desk workers. Fifteen participants (10 male, 35.8 +/- 10.2 yr, body mass index: 25.5 +/- 3.2 kg/m(2)) completed, on separate days, three 4-h conditions in a randomized order: 1) uninterrupted sitting (SIT), 2) sitting with 2-min light-intensity walking breaks every 30 min (2WALK), or 3) sitting with 8-min light-intensity walking breaks every 2 h (8WALK). At baseline and 4 h, middle cerebral artery blood flow velocity (MCAv) and CO2 reactivity (CVR) of the MCA and carotid artery were measured using transcranial Doppler (TCD) and duplex ultrasound, respectively. Cerebral autoregulation (CA) was assessed with TCD using a squatstand protocol and analyzed to generate values of gain and phase in the very low, low, and high frequencies. There was a significant decline in SIT MCAv (- 3.2 +/- 1.2 cm/s) compared with 2WALK (0.6 +/- 1.5 cm/s, P = 0.02) but not between SIT and 8WALK (- 1.2 +/- 1.0 cm/s, P = 0.14). For CA, the change in 2WALK very low frequency phase (4.47 +/- 4.07 degrees) was significantly greater than SIT (- 3.38 +/- 2.82 degrees, P = 0.02). There was no significant change in MCA or carotid artery CVR (P > 0.05). Results indicate that prolonged uninterrupted sitting in healthy desk workers reduces cerebral blood flow; however, this is offset when frequent short-duration walking breaks are incorporated.NEW & NOTEWORTHY Prolonged uninterrupted sitting in healthy desk workers reduces cerebral blood flow. However, this reduction in cerebral blood flow is offset when frequent short-duration walking breaks are incorporated into this sitting period. For those who engage in long periods of sedentary behavior, chronically breaking up these sitting periods with frequent active break strategies may have important implications for cerebrovascular health; however, further research should explore this hypothesis.