A Perspective on Crocus sativus L. (Saffron) Constituent Crocin: A Potent Water-Soluble Antioxidant and Potential Therapy for Alzheimer's Disease
A Perspective on Crocus sativus L. (Saffron) Constituent Crocin: A Potent Water-Soluble Antioxidant and Potential Therapy for Alzheimer's Disease
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DOI：
10.1021/acs.jafc.6b04398
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发表时间：
2017-02-08
影响因子：
6.1
通讯作者：
Gao, Song
中科院分区：
文献类型：
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作者：
Finley, John W.;Gao, Song
阿尔茨海默病（AD）是最常见的痴呆症，其中脑细胞的死亡导致记忆丧失和认知能力下降。有几个因素被认为在AD的发展和过程中起作用。现有的医学疗法只能适度缓解和延迟认知症状。目前的研究集中在开发抗体以去除淀粉样蛋白-β（A β）和tau蛋白的聚集体。这种方法已经实现了A β的去除;然而，没有AD患者的认知改善的报道。研究了番红花（Crocus sativus L.）特别是其主要成分藏红花素，已被广泛研究用于许多病症，包括痴呆和创伤性脑损伤。藏红花素是一种独特的抗氧化剂，因为它是一种水溶性类胡萝卜素。藏红花素已显示出改善学习和记忆以及保护脑细胞的潜力。对近年来发表的关于西红花苷和西红花苷对AD的影响以及西红花苷对A β和tau蛋白的影响的研究进行了检索。本文综述了西红花苷在脑内具有多功能保护作用，有望成为预防或治疗AD的补充剂或药物。
Alzheimer's disease (AD) is the most common form of dementia, in which the death of brain cells causes memory loss and cognitive decline. Several factors are thought to play roles in the development and course of AD. Existing medical therapies only modestly alleviate and delay cognitive symptoms. Current research has been focused on developing antibodies to remove the aggregates of amyloid-beta (A beta) and tau protein. This approach has achieved removal of A beta; however, no cognitive improvement in AD patients has been reported. The biological properties of saffron, the dry stigma of the plant Crocus sativus L., and particularly its main constituent crocin, have been studied extensively for many conditions including dementia and traumatic brain injury. Crocin is a unique antioxidant because it is a water-soluble carotenoid. Crocin has shown potential to improve learning and memory as well as protect brain cells. A search of the studies on saffron and crocin that have been published in recent years for their impact on AD as well as crocin's effects on A beta and tau protein has been conducted. This review demonstrates that crocin exhibits multifunctional protective activities in the brain and could be a promising agent applied as a supplement or drug for prevention or treatment of AD.