EXPRESSION OF THE HOMEOBOX HOX-4 GENES AND THE SPECIFICATION OF POSITION IN CHICK WING DEVELOPMENT
EXPRESSION OF THE HOMEOBOX HOX-4 GENES AND THE SPECIFICATION OF POSITION IN CHICK WING DEVELOPMENT
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DOI：
10.1038/350585a0
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发表时间：
1991-04-18
期刊：
影响因子：
64.8
通讯作者：
DUBOULE, D
中科院分区：
文献类型：
--
作者：
IZPISUABELMONTE, JC;TICKLE, C;DUBOULE, D
鸡的HOX-4同源基因，像小鼠的同源基因一样，在翅膀发育过程中在部分重叠的结构域中协调表达。局部应用维甲酸可以诱导HOX-4基因的从头转录。通过这种方式获得的Hox-4基因表达的镜像模式与随后的数字镜像模式的发展相关。HOX-4基因可能编码位置信息。
The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.