Pt(Me-Duphos)-catalyzed asymmetric hydrophosphination of activated olefins: Enantioselective synthesis of chiral phosphines
Pt(Me-Duphos)-catalyzed asymmetric hydrophosphination of activated olefins: Enantioselective synthesis of chiral phosphines
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DOI：
10.1021/om990882e
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发表时间：
2000-03-20
期刊：
影响因子：
2.8
通讯作者：
Rheingold, AL
中科院分区：
文献类型：
--
作者：
Kovacik, I;Wicht, DK;Rheingold, AL
催化剂前体铂(R，R-Me-Duphos)(反式-二苯乙烯)(1)催化的活性烯烃的不对称氢磷化反应(1)得到了在磷或碳中心具有立体化学控制的手性膦，1的化学计量反应允许观察P-H氧化加成、非对映选择性烯烃插入和还原消除步骤，这些步骤组成了所提出的催化循环。
Platinum-catalyzed asymmetric hydrophosphination of activated olefins using the catalyst precursor Pt(R,R-Me-Duphos)(trans-stilbene) (1) gives chiral phosphines with control of stereochemistry at phosphorus or carbon centers, Stoichiometric reactions of 1 allow observation of P-H oxidative addition diastereoselective olefin insertion, and reductive elimination steps, which make up the proposed catalytic cycle.