KINETICS OF TISSUE α‐TOCOPHEROL DEPLETION AND REPLETION
KINETICS OF TISSUE α‐TOCOPHEROL DEPLETION AND REPLETION
复制标题
组织 α-生育酚消耗和补充的动力学
DOI：
10.1111/j.1749-6632.1972.tb27874.x
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发表时间：
1972
影响因子：
5.2
通讯作者：
J. G. Bieri
中科院分区：
文献类型：
--
作者：
J. G. Bieri
维生素E的生理作用的理论基础，以及我们试图评估维生素的营养状况，是对维生素在身体组织中的动力学的理解。尽管经过了30多年的调查。对于不同组织在消耗过程中损失维生素E的速率，或者当维生素E持续存在于饮食中时积累维生素E的速率，我们仍然没有一个清晰的图像。在消耗的情况下，Witting及其同事发现，在大鼠中，当从断奶开始消耗时，a-生育酚的全身浓度急剧下降四周，然后以慢得多的速度下降。在喂食饱和或不饱和脂肪的大鼠中，生育酚的损失相似。德雷珀和Csallanyz报告称，在喂食缺乏饮食的大鼠和家兔中，肝脏α-生育酚迅速下降数周，然后达到平台，而肌肉中α-生育酚浓度的下降速度要慢得多。维生素E在体内积累的研究，虽然更多，但通常仅限于一个组织或只考虑了一个或两个点，目前的研究旨在填补我们对维生素E代谢知识的空白。我们已经检查了六个组织，在间隔，在年轻和成熟的大鼠经历维生素E耗尽7至10周。对于饱食（或蓄积）研究，以长达25周的间隔分析了来自喂食三种饮食水平的α-生育酚的幼鼠的七个组织。
Fundamental to our theories of the physiological action of vitamin E, and to our attempts to evaluate the nutritional status of the vitamin, is an understanding of the dynamics of the vitamin in body tissues. In spite of 30 years or more of investigation. we still do not have a clear picture of the rates at which different tissues lose vitamin E during depletion or accumulate it when it is continuously present in the diet. In the case of depletion, Witting and colleagues' found that in rats, the whole body concentration of a-tocopherol, when depleted from weaning on, fell precipitously for four weeks then declined at a much slower rate. The loss of tocopherol was similar in rats fed saturated or unsaturated fat. Draper and Csallanyz reported that in rats and rabbits fed a deficient diet, liver a-tocopherol decreased rapidly for several weeks, then reached a plateau, whereas the muscle concentration of a-tocopherol declined much more slowly. Studies of vitamin E accumulation in the body, though more numerous, have generally been restricted to one tissue or have considered only one or two points in The present studies were designed to fill these gaps in our knowledge of vitamin E metabolism. We have examined six tissues, at intervals, in both young and mature rats undergoing vitamin E depletion for seven to ten weeks. For the repletion (or accumulation) studies, seven tissues from young rats fed three dietary levels of a-tocopherol were analyzed at intervals of up to 25 weeks.