A novel approach to advanced carcinoma of the tongue: Cases successfully treated with combination of superselective intra-arterial chemotherapy and external/high-dose-rate interstitial radiotherapy
A novel approach to advanced carcinoma of the tongue: Cases successfully treated with combination of superselective intra-arterial chemotherapy and external/high-dose-rate interstitial radiotherapy
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DOI：
10.1093/jjco/hyl111
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发表时间：
2006-12-01
影响因子：
2.4
通讯作者：
Fukuda, Satoshi
中科院分区：
文献类型：
--
作者：
Nishioka, Takeshi;Homma, Akihiro;Fukuda, Satoshi
目的：本研究旨在评估一种新的治疗方案，动脉内顺铂输注加外部/高剂量率radiotherapy.Methods的有效性和安全性：超选择性动脉内顺铂输注（100-120毫克）进行伴随着外部放疗在4例局部晚期舌癌。所有患者在联合治疗后进行高剂量率近距离放射治疗。外照射后行后装治疗，每日2次，每次600 c戈伊，总剂量30-48戈伊。无血管或神经系统并发症。所有患者均发生III级急性放射性粘膜炎，但这并不需要中断治疗。平均随访期为35个月，局部区域控制获得所有patients.Conclusions：每周一次的动脉内顺铂加外部/高剂量率放疗的组合似乎有效的晚期舌癌。
Objective: This study sought to evaluate the efficacy and safety of a novel treatment regimen, intra-arterial cisplatin infusion plus external/high-dose-rate radiotherapy.Methods: Superselective intra-arterial infusion of cisplatin (100-120 mg) was performed concomitantly with external radiotherapy in four patients with locally advanced carcinoma of the tongue. A high-dose-rate brachytherapy boost was performed after combination therapy in all patients. Brachytherapy was performed after external radiotherapy, and the treatment schedule was twice daily, with a fraction of 600 cGy up to a total of 30-48 Gy.Results: All patients completed the therapy as scheduled. There were no vascular or neurological complications. Grade III acute radiation mucositis developed in all patients but this did not necessitate a treatment break. With a mean follow-up period of 35 months, loco-regional control was obtained for all patients.Conclusions: The combination of weekly administration of intra-arterial cisplatin plus external/high-dose-rate radiotherapy seems effective for advanced carcinoma of the tongue.