Biomimetic Asymmetric Hydrogenation: In Situ Regenerable Hantzsch Esters for Asymmetric Hydrogenation of Benzoxazinones
Biomimetic Asymmetric Hydrogenation: In Situ Regenerable Hantzsch Esters for Asymmetric Hydrogenation of Benzoxazinones
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DOI：
10.1021/ja208073w
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发表时间：
2011-10-19
影响因子：
15
通讯作者：
Zhou, Yong-Gui
中科院分区：
文献类型：
--
作者：
Chen, Qing-An;Chen, Mu-Wang;Zhou, Yong-Gui
催化量的Hantzsch酯，可以再生原位钌配合物在氢气下已被用于仿生不对称氢化苯并恶嗪酮与高达99%ee手性磷酸的存在下。使用氢气作为Hantzsch酯再生的还原剂使该氢化成为理想的原子经济方法。
A catalytic amount of Hantzsch ester that could be regenerated in situ by Ru complexes under hydrogen gas has been employed in the biomimetic asymmetric hydrogenation of benzoxazinones with up to 99% ee in the presence of chiral phosphoric acid. The use of hydrogen gas as a reductant for the regeneration of Hantzsch esters makes this hydrogenation an ideal atom economic process.